Top 100 ICU Papers – Fluid and Transfusion Therapy


The SAFE Study Investigators
A comparison of albumin and saline for fluid resuscitation in the intensive care unit.
NEJM 2004,350,2247-2256 Finfer
“See? Told you albumin was safe!” “See? Told you it was no better than crystalloid!” 

Vincent JL, Sakr Y, Reinhart K, Sprung CL, Gerlach H, Ranieri VM; the ‘Sepsis Occurrence in Acutely Ill Patients’ investigators
Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study.
Crit Care 2005,9,R745-54 Vincent
Albumin: SAFE as SOAP?

SAFE Study Investigators; Myburgh J, Cooper DJ, Finfer S, Bellomo R, Norton R et al.
Saline or albumin for fluid resuscitation in patients with traumatic brain injury.
NEJM 2007,357,874-884 SAFE Study Investigators
So what do the Lund protocol guys have to say about that?


Walsh TS, Saleh EE.
Anaemia during critical illness.
BJA 2006,97,278-291 Walsh
An excellent review of a core DICM exam topic

Marik PE, Corwin HL.
Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature.
CCM 2008,36,2667-2674 Marik
A massive cohort meta-analysis to back up the findings of the TRICC Study

Aronson D, Dann EJ, Bonstein L, Blich M, Kapeliovich M et al.
Impact of red blood cell transfusion on clinical outcomes in patients with acute myocardial infarction.
Am. J. Cardiol. 2008,102,115-119 Aronson
Isn’t it funny how someone always publishes a key paper just a couple of months after someone else does a comprehensive review?

Marik PE, Corwin HL.
Acute lung injury following blood transfusion: expanding the definition.
CCM 2008,36,3080-3084 Marik
An up-to-date review of a popular exam topic

No Comments

Be the first to start the conversation!

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s