Top 100 ICU Papers – Head Injury


Edwards P, Arango M, Balica L, Cottingham R, El-Sayed H, Farrell B, Fernandes J et al. CRASH trial collaborators.
Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months.
Lancet 2005,365,1957-1959 Edwards
Oh well, that answers that one then……….. now for CRASH 2

Peterson K, Carson S, Carney N.
Hypothermia treatment for traumatic brain injury: a systematic review and meta-analysis.
Journal of Neurotrauma 2008; 25: 62-71. PubMed Abstract
Well, pneumonia we can treat – death we haven’t quite mastered

Mauritz W, Steltzer H, Bauer P, Dolanski-Aghamanoukjan L, Metnitz P
Monitoring of intracranial pressure in patients with severe traumatic brain injury: an Austrian prospective multicenter study.
ICM 2008,34,1208-1215 Mauritz
More (circumstantial) evidence that ICP monitoring does not help improve outcome – but don’t let that stop you!

Tisdall MM, Smith M.
Cerebral microdialysis: research technique or clinical tool.
BJA 2006,97,18-25 Tisdall
Is this the monitoring of the future? (and it’s not just for brains…..)

Grande PO.
The “Lund Concept” for the treatment of severe head trauma – physiological principles and clinical application.
ICM 2006,32,1475-1484 Grände
A sudden burst of journal interest in the Lund Concept – but still no RCT……………?

Cotton BA, Snodgrass KB, Fleming SB, Carpenter RO, Kemp CD et al.
Beta-blocker exposure is associated with improved survival after severe traumatic brain injury.
J Trauma 2007,62,26-35 Cotton
Perhaps beta-blockers are the key element of Lund therapy? Supportive evidence from Arbabi et al.

Muchow RD, Resnick DK, Abdel MP, Munoz A, Anderson PA.
Magnetic resonance imaging (MRI) in the clearance of the cervical spine in blunt trauma: a meta-analysis.
Journal of Trauma 2008; 64: 179-89J Trauma 2008,64,179-189 Muchow
MRI? Hassle? If it means getting rid of the collar and log-rolling, I’ll take it!

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