Top 100 ICU Papers – Renal Support


Friedrich JO, Adhikari N, Herridge MS, Beyene J.
Meta-analysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death.
Annals of Internal Medicine 2005; 142: 510-24 PubMed Abstract     AIM Full Text
Is this the final, final nail in the coffin of renal-dose dopamine?

Morelli A, Ricci Z, Bellomo R, Ronco C, Rocco M, Conti G et al.
Prophylactic fenoldopam for renal protection in sepsis: a randomized, double-blind, placebo-controlled pilot trial.
Critical Care Medicine 2005; 33: 2451-6. PubMed Abstract
Is this the new renal dopamine? Not only does it reduce renal failure, it may even improve mortality…

Ho KM, Sheridan DJ.
Meta-analysis of frusemide to prevent or treat acute renal failure.
BMJ 2006,333,420 Ho
Treating oliguria with frusemide is like – um – p—ing in the wind…..?

Kelly AM, Dwamena B, Cronin P, Bernstein SJ, Carlos RC.
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy.
Ann Intern Med 2008,148,284-294 Kelly
N-acetylcysteine, sure – NaBic, yes – Vitamin C? – Theophylline?!


VA/NIH Acute Renal Failure Trial Network: Palevsky PM, Zhang JH, O’Connor TZ, Chertow GM, Crowley ST et al.
Intensity of renal support in critically ill patients with acute kidney injury.
N Engl J Med 2008,359,7-20 VANIH Acute Renal Failure Trial Network
But this was rather different to Ronco’s study……? 


Tolwani AJ, Campbell RC, Stofan BS, Lai KR, Oster RA, Wille KM.
Standard versus high-dose CVVHDF for ICU-related acute renal failure.
Journal of the American Society of Nephrology 2008; 19: 1046-8
Hang on – lower mortality, but higher rate of ESRF?
The RENAL Trial (
 N Engl J Med 2009,361,1627-1638 RENAL ) makes it all clear


Pannu N, Klarenbach S, Wiebe N, Manns B, Tonelli M; Alberta Kidney Disease Network.
Renal replacement therapy in patients with acute renal failure: a systematic review.
JAMA 2008,299,793-805 Pannu
The sum total of all we know about RRT, contained in one systematic review.

No Comments

Be the first to start the conversation!

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s